上海浦东品茶

　　Recently, the urban comedy "One Car and Four Servants" starring Wang Zijian, Hu Xinger, Yuan Chengjie and Fuxiang Zhong officially released a poster and a preview, which will land in the national cinema on November 16th to celebrate the New Year in advance.

　　In the finalized poster, Wang Zijian, dressed in a suit, looks like a successful person, while Hu Xinger holds a baseball bat and is full of women’s breath; Yuan Chengjie incarnates as a small white-collar worker in the city, and Fuxiang Zhong is full of stories. Four people with different identities, standing or sitting, standing or lying down, gather in a car, and it seems that a happy drama will be staged. The title of "One Car with Four Servants" shows that a complicated and interesting New Year comedy will be staged between the four people.

　　In the era when Pinduoduo is rampant, you have to organize a group to buy an apple. In order to save some poor wages, white-collar workers with tight funds poured into the "group army". In "One Car and Four Servants", Wang Zijian, Hu Xinger and other four people started a bolder attempt — — Fight for a car.

　　In the preview, Wang Zijian, a small boss in the wine business, Hu Xinger, a fashion designer who runs a personal studio, Fuxiang Zhong, a diaosi actor who wants to be a big star, and Yuan Chengjie, a car enthusiast, all need a luxury car as a facade for various reasons. However, the four people who are short of money can’t afford a luxury car, so by chance, four people who met by accident suddenly had a whim to buy a car in partnership, and a strange "car owner" was formed. The luxury car brought surprises to the ordinary life of the four people, but it caused a series of troubles, and the original beautiful life became unpredictable embarrassment and embarrassment.

　　The ideal has always been beautiful, but the reality is often very bad. On the road of carpooling, the four protagonists not only have to face frequent financial crises and internal frictions, but also the "pit car group" composed of more than a dozen gold comedians is the strength to steal the mirror. All kinds of unexpected surprises make several protagonists feel at a loss and full of jokes. On November 16th, "One Car and Four Servants" celebrated the New Year in advance, and brought you a wild smile!

On April 18th, the 20th Shanghai International Automobile Industry Exhibition will open soon.Mercedes-Benz will present a lineup of 27 heavy-duty models with one world premiere, five China firsts and seven China-listed models at Hall 4.1 of the Shanghai International Auto Show.. All brand matrices of Mercedes-Benz, Mercedes -EQ, Mercedes-Maibakh, Mercedes -AMG and G-class off-road vehicles under the Trident Star Emblem are assembled.

　　Three latest Mercedes-Maibakh products covering pure electric, hybrid and high definition will be released soon. Mercedes-Maibakh’s first mass-produced pure electric vehicle, the new Mercedes-Maibakh EQS pure electric SUV, will make its world debut during the auto show. Mercedes-Maibakh brand’s first plug-in hybrid car-Mercedes-Maibakh S 580 e plug-in hybrid car, and Mercedes-Maibakh S-class Haute Voiture limited edition will be listed together.

[New Mercedes-Maibakh EQS pure electric SUV]

[Mercedes-Maibakh S 580 e plug-in hybrid car]

[Mercedes-Maibakh S-class Haute Voiture limited set]

　　The EQG concept car, the first pure electric vehicle in the history of G-class off-road vehicle, will usher in the first show in China, and the EQG concept car will show its impressive strength by virtue of its powerful 4×4 all-wheel drive system with four independently controllable motors.

　　The new EQE pure electric SUV will usher in the first show in China. As the first domestic luxury pure electric SUV developed based on EVA pure electric platform, the new EQE pure electric SUV will set a market benchmark in terms of luxury, comfort, safety and technology with all-round strength, and bring all-powerful pure electric travel experience to China customers. In addition, a new generation of Mercedes-Benz GLE SUV will make its debut in China.

[New EQE pure electric SUV]

[New generation Mercedes-Benz GLE SUV]

　　The new Mercedes-Benz long-wheelbase GLC SUV, which was pre-sold recently, will be officially launched at the auto show. As an important member of the domestic Mercedes-Benz family, the new long-wheelbase GLC SUV has added three rows and seven seats, making it the first model in the luxury medium-sized SUV market to offer both five-seat and seven-seat options, and at the same time, it has customized many exclusive upgrades for China customers.

　　The S-class sedan family is about to welcome two new cars on the market: the Mercedes-Benz S 450 e L plug-in hybrid sedan equipped with the latest generation of plug-in hybrid technology, and the Mercedes-Benz S-class sedan that provides a variety of customized choices such as car paint and interior, which brings multiple respected choices for high-grade customers.

[Mercedes-Benz S 450 e L]

"Mercedes-Benz S-Class sedan ingenious version"

　　At this auto show, Mercedes -AMG brought a number of latest masterpieces showing luxury performance and forward-looking innovation. The most powerful S-class sedan in history-the new Mercedes -AMG S 63 E PERFORMANCE prototype special edition will debut in China market. As the third production model of Mercedes -AMG family applying E PERFORMANCE hybrid technology from F1 racing car, this new work has achieved the perfect combination of excellent performance and comfortable experience with many forward-looking technologies.

[Mercedes -AMG S 63 E PERFORMANCE pre-production special edition]

[Mercedes -AMG GLS 63 4MATIC+]

[New Mercedes -AMG pure electric EQE 53 4MATIC+]

[Mercedes -AMG C 43 4MATIC Travel Car Special Edition]

　　The newly launched Mercedes -AMG GLS 63 4MATIC+ will also make its debut in China. Mercedes -AMG’s second mass-produced pure electric vehicle, the brand-new Mercedes -AMG pure electric EQE 53 4MATIC+, and the brand-new Mercedes -AMG C 43 4MATIC touring car special edition equipped with "one person, one machine" M139 2.0T engine will be on the market, igniting driving passion with surging performance.

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　　Guangzhou Daily News (all-media reporter Liu Xiaoxing) Since 2021, Guangzhou has implemented the reform of the enrollment system for high school examinations. The reform of the senior high school entrance examination promoted under the unified deployment of the higher authorities implements a new academic level examination system, a new comprehensive quality evaluation method for students and a new enrollment and admission mechanism. Yesterday, Guangzhou Education Bureau issued the "Implementation Plan of Guangzhou Junior High School Academic Level Examination for Chinese, Mathematics, English Morality, Law, History, Physical Chemistry and other subjects (Trial)", and answered the questions of candidates and parents in detail.

　　From 2021 to 2023, the examination for admission and scoring subjects of Guangzhou junior high school academic level examination will be held from June 20 to 22 every year. The admission scoring subject adopts the "4+4" model, and the history exam is added, with a score of 90 points and a sports score of 70 points. The scores of language, mathematics and English were adjusted to 120. The score of morality and rule of law is adjusted to 90. Physical and chemical scores remain unchanged, with 100 points each.

　　In terms of test questions, Chinese has added additional questions to encourage students to read more books, and appropriately widen the discrimination of Chinese test questions in a reasonable way. The number of questions in mathematics subjects remains unchanged, and the score of solving questions decreases. The spelling of words in the writing section of English subject is changed to text filling, and the number of questions in some types of questions decreases slightly with the shortening of the examination duration. The 100 points in physics and chemistry include 10 points in experimental operation.

　　Focus question and answer: How do schools and students adapt to the new senior high school entrance examination?

　　1. What are the admission scoring subjects?

　　A: According to the "Implementation Opinions of the Guangdong Provincial Department of Education on Further Promoting the Reform of the Enrollment System for Senior High School Examinations" (Guangdong Education Examination [2017] No.15), "In addition to the four subjects of Chinese, mathematics, foreign languages, physical education and health, at least four subjects of morality and rule of law, history, physics and chemistry should be taken as enrollment subjects for senior high schools, and six subjects should be encouraged to be taken as enrollment subjects for senior high schools." The admission scoring subjects in our city adopt the "4+4" model, that is, eight subjects such as Chinese, mathematics, English (including English listening and speaking), sports and health, morality and rule of law, history, physics and chemistry are taken as admission scoring subjects.

　　Compared with the current senior high school entrance examination policy, it has added history subjects, which embodies the basic role of history subjects and strengthens the effective connection with the "3+1+2" model of comprehensive reform of college entrance examination in our province.

　　2. Who are the test subjects?

　　A: The subjects of the examination are the fresh graduates of junior high schools in our city from 2021 to 2023, and the returning students and former students who applied for ordinary high schools in our city.

　　3. How to arrange the exam?

　　A: The "Implementation Opinions of Guangzhou Education Bureau on Further Deepening the Reform of the Enrollment System for Senior High School Examinations" (Sui Jiao Gui Zi [2018] No.8) stipulates that the examinations of physics and chemistry, morality and rule of law and history are subject to "no examination papers". The two subjects of the joint examination are arranged to take the examination in turn at the same session, and the examination papers are sent and received separately. The examination papers are sent and received for 15 minutes in the middle of the examination, during which candidates are not allowed to leave the examination room in principle.

　　4. What should junior high schools do?

　　A: The school should strictly implement the curriculum plan, curriculum standard and curriculum plan, adhere to the principle of "five educations", guide teachers to deeply understand the subject characteristics, knowledge structure and thinking methods, scientifically grasp the students’ cognitive laws, and do a good job in every class.

　　Chinese subject should pay special attention to setting situations and putting forward tasks, so that students can learn and use language in practice, help students express themselves in real language communication environment, achieve the combination of learning and application, and develop students’ language ability. In addition, it is necessary to strengthen the implementation of reading famous books in unified textbooks.

　　The number of questions in mathematics is unchanged, the objective questions are unchanged, and the answers are reduced. Based on the curriculum standards, we should make good use of teaching materials, ensure the score of objective questions, attach importance to cultivating students’ mathematical thinking and avoid falling into "routine" training. Pay due attention to the change of the topic orientation of the college entrance examination and the new curriculum standard of senior high school, pay attention to the connection between junior high school and senior high school, and strengthen the application of mathematics.

　　English subjects should pay attention to the guidance of students’ correct values in the process of language learning. Consolidate the basic knowledge of phonetics, vocabulary and grammar, learn discourse knowledge, and develop students’ thinking ability in understanding, interpreting, analyzing, inferring, evaluating and creating texts. Special attention should be paid to increasing high-quality language input in and out of class and strengthening reading training.

　　The teaching of ethics and rule of law should be based on the curriculum standards, make good use of the textbooks compiled by the state, and implement the fundamental task of educating people; Structuring the teaching content with the concept of discipline as the core and contextualizing the teaching content with the theme as the guide; Benchmark academic quality evaluation standards, highlight the cultivation of students’ ability to apply what they have learned, and avoid aggravating students’ memory burden because of closed-book exams.

　　History discipline should deeply understand the curriculum standards, make good use of unified textbooks, adhere to the correct ideological orientation and value judgment, pay attention to guiding students to deepen their understanding of history on the basis of mastering the basic knowledge of Chinese and foreign history, and improve their historical reading ability and historical thinking ability.

　　According to the proposition of curriculum standards, teachers should correctly understand the curriculum standards, make good use of textbooks, make good use of the materials in textbooks, guide students to substitute more physical perspectives in their daily life observation and experience, and be willing to explore the principles of physics in life. Strengthen the cultivation of information acquisition and arrangement, critical thinking, experimental exploration, and expression of physical terms, and implement experimental operation skills in ordinary teaching.

　　Chemistry discipline should attach importance to cultivating and maintaining students’ interest in learning chemistry, strengthen the cultivation of basic chemistry concepts and discipline thinking modes, disperse the burden and pressure of chemical language learning, let students enter the laboratory more, and ensure that the basic operations involved in the eight basic experiments stipulated in the curriculum standards pass the test.

　　5. What should students do?

　　A: Students should conscientiously do well in every class of all subjects. In addition to mastering solid basic knowledge and skills, they should also pay attention to the cultivation of subject thinking and be good at applying the knowledge and methods learned from books to real and complex problem solving. In the study of all subjects, we should strengthen reading and improve the ability of information processing and written expression. Pay attention to social life, current political hotspots and scientific and technological development, and closely combine subject learning with life practice. Take seriously the experimental practice of physics, chemistry and other subjects, use your brains and do more, and improve your scientific inquiry ability.

On the list of the best coaches in the history of world football by IFFHS (International Federation of Football History and Statistics), Mourinho won the active championship with 242 points, beating Guardiola with 221 points. Coupled with the coach who has retired to the second line, Mu Shuai ranked second with 257 points, and Ferguson ranked first in history. The top ten are Ferguson, Mourinho, Guardiola, Wenger, Loew, Ancelotti, Bosco, Simone, Lippi and Deschamps.

The selection mechanism is regarded as a fair bureau, which scores according to the annual ranking of each category, including the world football year national team coach list and the club coach list in. The first place gets 20 points, the second place gets 19 points, the third place gets 18 points, and so on. The 20th place gets 1 point, and those below 20 places won’t get points.

According to this list, Mu Shuai is undoubtedly the highest in the world and the highest in scores among active coaches. What’s important is that Mourinho’s success has a high gold content, and it’s hard for anyone to repeat it. The most important honor is to lead Porto, who has a relatively flat and mediocre lineup, to complete the Europa League and the Champions League in succession, and to achieve the triple crown, the Manchester United low-ebb triple crown and the European champion in Rome together with Inter Milan, which is also unpopular.

Obviously, unlike other coaches, Mourinho led the team without paying attention to the morale and unity of the team, and was good at making a division of iron and blood. He played a super-large whole with a seemingly ordinary lineup and propped up his team’s victory in five finals in Europe. As a result, wherever Mourinho goes, there will be a group of die-hard players, and even many people say that "a scholar dies for a confidant", and his personality charm is full, which is a double-edged sword for Mu Shuai’s coaching. Some people who don’t listen to him will directly become thorns. Bogba is a good example.

At present, Mu Shuai has turned the team into a division of iron and blood in Rome, and has performed strongly in the double track of Serie A and Europa League. In the 26th round of Serie A against Sassuolo, after winning, he will catch up with Inter Milan, which ranks second in the standings, and get 50 points. The European War is expected to reappear the myth of coaching Porto, leading the team to win the European Championship for two consecutive years and at different levels, and now it has entered the top 8 of the Europa League with one foot. However, Mu Shuai himself was in trouble. He scolded the fourth official and got a red card when he lost 1-2 to Cremonese in round i24 in a store. Later, Mu Shuai received a fine, suspended for two games and imposed a fine of 10,000 euros. He chose a hard bar and filed a lawsuit directly with the referee group, because the fourth official provoked a scolding battle, and then asked the referee to show a red card, suggesting that the referee deliberately manipulated the game.

In the process of bringing a lawsuit against the referee, the heavy penalty suffered by Mu Shuai has not been implemented. Mu Shuai led his team to beat Juventus 1-0 and Real Sociedad 2-0 in the past two games. Now Mu Shuai’s heavy penalty came into effect on March 11th. The Italian Football Association confirmed that Mu Shuai failed to file a lawsuit against the referee. After the heavy penalty came into effect, Mu Shuai issued a document to protest and made a handcuff gesture directly to express his strong dissatisfaction. This gesture was only during his coaching at Inter Milan. Then Mourinho will not be able to improvise the 26th round of Serie A between Rome and Sassuolo and 27th round between Rome and Lazio, and the second round of the Europa League quarter-final will not be affected by the League.

Faced with the aging population and the rising prevalence of various chronic diseases, reasonable and scientific health risk assessment and management are helpful to better control personal and overall medical expenses and protect personal health interests to the greatest extent.

In recent years, the advantages of retinal image AI in health risk assessment have been shown. What advantages does it have? What value can it bring to the physical examination center and related departments?

At the Frontier Innovation and Wisdom Forum of the 9th 301 Discussion on Health and the 11th Summit Forum of Directors of National Physical Examination Center,Professor Tang Shiqi, deputy director of Health Management Branch of Chinese Medical Association, president of Hubei Health Management Society and academic leader of Health Management Center of Wuhan University People’s Hospital.Make a wonderful share with the title "Retinal Image AI Helps Health Risk Assessment".

In her speech, she pointed out:"Apart from the loss of life, there is nothing more frightening than the loss of vision. It is suggested that fundus photography should be added to chronic disease screening, eye health should be included in chronic disease system, fundus examination should be paid attention to, and the threshold should be moved forward to realize early detection and diagnosis of chronic diseases. "

The transcript of the speech is edited as follows:

Thank you very much for your introduction. The topic I share with you below is "Retinal Image AI Helps Health Risk Assessment". I will share it with you from four aspects, namely, the current situation of fundus diseases, retina as the best health assessment window, assessment of various diseases through retina, and the application of artificial intelligence products of retinal images.

Present situation of fundus diseases

"The 14th Five-Year National Eye Health Plan" listed fundus diseases as the key eye diseases in the next five years for the first time, and proposed early detection, early diagnosis and early treatment to reduce the blindness rate of diseases.

The burden of fundus diseases is heavy. There are more than 40 million patients with fundus diseases in China, and the distribution of medical resources is still uneven. At present, as the most important blinding eye disease in China, the clinical status of fundus diseases can be said to have a long way to go. This is also the main reason why our country has made fundus diseases a new disease in the National Eye Health Plan of the 14th Five-Year Plan released this year.

our countrydiabetesThe prevalence rate has reached 10%~13%, among which the prevalence rate of diabetic retinopathy in diabetic population is as high as 15%~43%. Then the risk of blindness in diabetic patients is 50~80 times greater than that in non-diabetic patients.

hypertensionIt is a common cardiovascular disease. The incidence rate in China is 5.11%, and about 70% of patients have fundus diseases. With the development of the course of the disease, changes such as hemorrhage, hard exudation, lint spots and the like appear in the fundus, and papilledema may occur in severe cases.

Age-related macular degeneration.For those of us over 50 years old, about one in every six people has macular degeneration. Early detection, diagnosis and treatment of macular degeneration are of great significance to protect central vision and prevent blindness. Therefore, it is recommended that people over 50 years old have a routine eye examination every year.

Fundus lesion caused by high myopia.There are about 70 million people with myopia greater than 600 degrees in China. It is recommended to screen the fundus every six months to one year.

Therefore, we should promote the shift from blindness prevention to universal eye health, move the screening threshold forward, and improve the screening of diseases. At the same time, we should pay attention to the early screening of fundus diseases, expand the screening work and avoid irreversible blindness.

It is the best window for retinal health assessment.

There are very important structures in the fundus, including the optic nerve, retina, retinal arteries and veins, macular area, etc., and this is the area examined by the fundus.

Many fundus diseases have no obvious symptoms in the early stage and are difficult to be detected. However, the early stage is often the right time for treatment. Once missed, the lost vision may not be well recovered. 80%~90% of fundus diseases can be screened by taking a photo of fundus.

In addition, medical practice has proved that in addition to ophthalmic diseases, manyCardiovascular, neurological, endocrineOther diseases have obvious or even characteristic changes in the retina.

Evaluation of various diseases through retina

First of all.Diagnosis of diabetic retinopathy by retinal image AI. An SCI article published by Shibei Hospital, Jing ‘an District, Shanghai shows that artificial intelligence has high sensitivity and specificity in detecting sugar webs and proliferative sugar webs (the sensitivity and specificity of detecting sugar webs are 90.79%, 98.5%, AUC=0.946；; The sensitivity and specificity of detecting proliferative sugar net are 91.18%, 98.79%, AUC=0.950). It is feasible to carry out screening of sugar net based on artificial intelligence in community hospital outpatient department.

AI auxiliary diagnosis system for retinal diseases.This article of Zhongshan Eye Center of Sun Yat-sen University was published in the sub-issue of The Lancet, and its SCI impact factor was very high, reaching 24.519. Studies have confirmed that this "comprehensive intelligent diagnosis expert of fundus diseases" developed by Eagle Pupil Airdoc can identify 14 common fundus abnormalities, with an average AUC of 0.955, and it performs well in the screening of various fundus abnormalities.

Retinal image AI to judge ischemic cerebrovascular disease.This is also a paper published in Science Bulletin, a journal sponsored by China Academy of Sciences, with an impact factor of 11.78. The results verified by the team of Peking University Medical School and Tongren Hospital show that (the model) plays a positive role in early detection of high-risk groups of cardiovascular diseases, guiding active intervention, monitoring and evaluating the intervention effect.

The traditional evaluation method of ischemic cerebrovascular disease has many collection indexes, so it needs invasive collection. The blood test takes a certain time, 2~4 hours, so the calculation is complicated and it is difficult to popularize. The new evaluation method based on China’s cardiovascular risk prediction model is retinal image +AI deep learning algorithm, which only needs fundus photography, non-invasive collection, and the detection time is 1 minute, and the report can be made directly in about 1 minute.

Retinal image AI can also evaluate Alzheimer’s disease.The retina is a part of our brain tissue. The degeneration of cranial nerves is also reflected in the subtle changes of retina. Taking CAIDE≥10 copies as the classification standard for high-risk groups (CAIDE dementia risk score is a risk assessment tool for the general population), the retinal AI algorithm is superior to the traditional invasive and complex dementia assessment, that is, it can be assessed by taking retinal photographs.

Retinal AI can also evaluate anemia.Retinal photographs of patients with anemia are usually pale or pale in background, pale in optic disc, and mild edema. The veins are pale. According to the model of retinal artificial intelligence, the AUC of anemia is > 0.9.

Application of retinal artificial intelligence products

Eagle Eye’s products are very good. It has multi-dimensional products and services. First of all, their artificial intelligence auxiliary diagnosis software can screen fundus diseases and lesions, make auxiliary diagnosis and assess the health risk of systemic chronic diseases, and has comprehensive qualifications, including the first three types of ophthalmology certificates in China, including the second, third and CE certificates.

Has excellent performance. The accuracy, specificity and sensitivity are leading in the world, and it is suitable for all mainstream fundus cameras in the market, including Canon and Topcom.

In addition, there is an authoritative endorsement. Carry out the world’s largest real-world research, with the results published in The Lancet magazine; Won the Wu Wenjun Prize twice, the highest award of artificial intelligence in China.

Eagle Airdoc’s fundus camera has the advantages of pupil-free, full-automatic, self-help (no operator required) and no professional darkroom. It is a self-developed domestic camera with high cost performance.

But also provide operational support services. Performance support, training support, follow-up of positive cases, and review by superior medical institutions, the Internet and hospitals.

(For the physical examination center), the retina image AI of Eagle Pupil Airdoc has seven values:

First,Upgrade the ability of eye examination.It can be used for auxiliary diagnosis of fundus diseases and risk assessment of systemic chronic diseases.

Second,Improve the standardization of diagnosis and treatment.It is a registered product, with standardized report, stable state, authenticity and reliability.

Third,Increase the efficiency of effective physical examination centers.

Fourth,Improve academic ability.It can quantify and multi-dimensionally empower scientific research, and artificial intelligence can improve the probability of project application, and expand clinical research opportunities of multi-departments and multi-diseases.

Fifth,Make up for the shortage of ophthalmologists.Automatic shooting, without doctor’s operation, AI-assisted diagnosis of liberation ophthalmologist. Nurses can easily operate it, and it is suitable for in-hospital examination and external examination.

Sixth,It is convenient to check in many occasions.The equipment is small, easy to operate, intelligent and fast, and it can be used in the out-of-home medical examination vehicle, which is suitable for large-scale screening.

Seventh,Historical comparison and continuous management.Realize automatic historical comparison of multiple inspections.

To sum up, apart from the loss of life, there is nothing more frightening than the loss of eyesight. It is suggested that fundus photography should be added to chronic disease screening, eye health should be included in chronic disease system, fundus examination should be paid attention, and the threshold should be moved forward to realize early detection and diagnosis of chronic diseases. A photo of the fundus, early knowledge of the disease.