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At present, there are about hundreds of common anti-tumor drugs in clinic, which can be roughly divided into the following seven categories:

Cytotoxic drugs, hormone drugs, biological reaction regulators, monoclonal antibody drugs, immune checkpoint inhibitors, other drugs, auxiliary drugs, etc.

01, cytotoxic drugs

Drugs that act on the chemical structure of DNA

(1) alkylating agents and nitrogen mustard (such as nitrogen mustard, chlorambucil, cyclophosphamide, ifosfamide, melphalan, etc.), setipine (such as setipine, etc.), nitrosoureas (such as carmustine and smectine, etc.) and methanesulfonate (such as busulfan, etc.).

(2) Platinum compounds: such as cisplatin, carboplatin and oxaliplatin.

(3) Mitomycin: such as mitomycin, etc.

Drugs that affect nucleic acid synthesis

(1) dihydrofolate reductase inhibitors: such as methotrexate and pemetrexed.

(2) Thymidine synthase inhibitors: such as 5-FU, FT-207, capecitabine, etc.

(3) Purine nucleotide synthase inhibitors: such as 6- mercaptopurine, 6-TG, etc.

(4) Nucleotide reductase inhibitors: such as hydroxyurea.

(5)DNA polymerase inhibitors: such as cytarabine and gemcitabine.

● Drugs that act on nucleic acid transcription selectively act on DNA templates to inhibit DNA-dependent RNA polymerase, thus inhibiting RNA synthesis: such as actinomycin D, daunorubicin, adriamycin, epirubicin, aclacinomycin, guangmycin, etc.

● Topoisomerase Ⅰ inhibitors acting on DNA replication: such as irinotecan, topotecan and hydroxycamptothecin.

● Drugs that mainly interfere with tubulin synthesis during mitosis M phase: such as paclitaxel, docetaxel, vinblastine, norvinblastine, podophylline, homoharringtonine, etc.

● Other cell poisons: such as asparaginase.

02, hormone drugs

(1) Anti-estrogen: such as tamoxifen, toremifene, exemestane, etc.

(2) Aromatase inhibitors: such as buprenone, Formetam, letrozole, anastrozole, etc.

(3) Progesterone: such as medroxyprogesterone acetate and megestrol acetate.

(4) Sex hormones: such as methyltestosterone, testosterone propionate and diethylstilbestrol.

(5) Anti-androgen: such as flutamide.

(6)RH-LH agonists/antagonists: such as goserelin and leuprorelin acetate.

03, biological reaction regulator

Mainly through the body’s immune function to inhibit tumors, including interferon, interleukin -2, thymopeptides.

04, monoclonal antibody drugs

Such as rituximab, trastuzumab and bevacizumab.

05, immune checkpoint inhibitor

Such as Pam monoclonal antibody, Cindilizumab, Trepril monoclonal antibody, Atzumab, etc.

06, other drugs

(1) Cell differentiation inducers: such as retinoids and arsenious acid.

(2) Apoptosis inducer.

(3) Inhibitor of angiogenesis: Endor.

(4) Epidermal growth factor receptor inhibitors: such as gefitinib and erlotinib.

(5) gene therapy.

(6) tumor vaccine, etc.

07, auxiliary medicine

(1) Blood-raising drugs: such as G-CSF/GM-CSF, IL-11/TPO, EPO, etc.

(2) Antiemetic drugs: such as ondansetron and granisetron hydrochloride.

(3) Analgesics: such as aspirin, acetaminophen, codeine, tramadol, morphine, fentanyl, etc.

(4) Osteoclast inhibitor: such as pamidronate disodium, zoledronic acid sodium, etc.

Editor | Li Yaqi Zhao Ruoxi

Revise | Zhang Fangfang

Editor-in-Chief Hong Wei

All knowledge of internal medicine diagnosis and treatment of cancer patients

Published by China Medical Science and Technology Press

This book is one of the fascicles of "Cancer Doctors Say", which mainly introduces the common sense, diagnosis and medical treatment of tumors, and focuses on the related problems of specific cancer types such as lung cancer, gastric cancer, pancreatic cancer and breast cancer. At the same time, it also shows real and touching stories in tumor prevention and treatment, giving strength to patients and their families. The book is introduced in detail in the form of questions and answers, and the language is easy to understand, which is suitable for readers, especially cancer patients and their families.

Original title: "Cancer Doctors say | What are the common anti-tumor drugs?"

Read the original text

"With the online’ intermediary supermarket’, our owners can easily and quickly choose an intermediary service agency with reasonable price and intimate service, which is very convenient for foreign enterprises." Ms. Wang, who used to find the evaluation company through the "intermediary supermarket", said that it was time-consuming and laborious to go to many places and compare qualifications and prices repeatedly.

In recent years, the district administrative examination and approval bureau has actively explored a new mode of project examination and approval service, comprehensively standardized and promoted the service of "intermediary supermarket", made full use of the advantages of centralized management, rich information and no face-to-face service of "intermediary supermarket", and solved the problem that it is difficult for project owners to find intermediary services.

"Intermediary supermarket" service refers to an online trading platform that provides fair, just, unified and efficient administrative examination and approval intermediary services for clients and intermediaries. Various intermediary service agencies such as EIA preparation, planning preparation and engineering consultation are classified and "placed" like goods, and the service content, charging standard and contact telephone number are clear at a glance. Enterprises can choose their favorite intermediary agencies to provide services for themselves like visiting Tmall online stores. At present, there are 114 intermediaries in the region, 110 intermediaries have been registered, and 77 contracts have been signed through "intermediary supermarkets".

The owner unit publishes the procurement announcement through the official platform, and all qualified intermediaries can participate in the bidding. The owner unit will review and screen the bidding companies, select the interested units and sign the contract online, and finally reach a deal. "The use of the’ intermediary supermarket’ is very convenient. The procurement subject and intermediary agencies do not need to go to the scene, and all of them are handled online, avoiding the cumbersome procedures such as multi-party consultation and business negotiation, effectively reducing our time and cost." Mr. Li, the person in charge of the aquaculture factory that just used the "intermediary supermarket", said.

The district administrative examination and approval bureau implements the service mode of "intermediary supermarket+deputy agent", provides one-to-one guidance for the inevitable problems encountered by enterprises in the process of selecting and handling, actively connects with intermediaries and procurement subjects, assists in solving various business problems encountered in the process of registration, entry, selection and evaluation, helps enterprises and procurement subjects to successfully complete transaction services, realizes the goal of online non-meeting service, and provides more convenient channels for the people to handle affairs and creates a better one.

In the next step, the district administrative examination and approval bureau will continue to increase the service of online "intermediary supermarkets", take the use experience and suggestions of the enterprise masses as the guide, innovate, further enhance the standardization and efficiency of intermediary services, reduce transaction costs, promote the reform of government services, continuously improve the quality and speed up, and enhance the experience and satisfaction of the enterprise masses.

Jing jiao Xin [2022] No.5

District Education Committees, Yanshan Education Committee, Social Affairs Bureau of Economic Development Zone, network offices of district committees, municipal universities, directly affiliated units, mobile application distribution platforms and educational mobile Internet application providers:

　　In order to conscientiously implement the relevant requirements of reducing the workload of students in compulsory education and the burden of off-campus training (hereinafter referred to as "double reduction") and promote the orderly and healthy development of educational mobile Internet applications (educational APP, hereinafter referred to as "educational mobile applications"), on the basis of the Notice of Beijing Municipal Education Commission and other eight departments on Forwarding the Opinions of the Ministry of Education and other eight departments on Guiding and Regulating the Orderly and Healthy Development of Educational Mobile Internet Applications, Further improve the working mechanism of Beijing’s educational mobile application audit and daily management, and promote the institutionalization and standardization of educational mobile application governance. After research, relevant matters are hereby notified as follows.

　　I. General requirements

　　In order to implement the Opinions on Further Reducing the Students’ Homework Burden and Off-campus Training Burden in Compulsory Education, the Regulations on the Management of Mobile Internet Application Information Services, the Notice of the General Office of the Ministry of Education and other six departments on changing the existing online discipline training institutions from filing to examination and approval, the Opinions of the Ministry of Education and other eight departments on guiding and standardizing the orderly and healthy development of mobile Internet applications in education, and the General Office of the Ministry of Education on promoting the management of educational mobile Internet applications Document requirements such as the Notice of Linking up with the "Double Reduction" Policy, further standardize the management of educational mobile applications, strengthen the post-event supervision of educational mobile applications in accordance with the Administrative Measures for the Filing of Educational Mobile Internet Applications, improve the service quality and guarantee level of educational mobile applications, and create a healthy, orderly and safe cyberspace and learning environment for teachers and students.

　　Second, the scope of filing

　　(A) the definition of educational mobile applications

　　According to the requirements of the Notice of the General Office of the Ministry of Education on Printing and Distributing the Administrative Measures for Filing Educational Mobile Internet Applications, the scope of filing educational mobile applications is: "Internet mobile applications with faculty, students and parents as the main users and education and learning as the main application scenarios, serving school education, teaching and management, students’ study and life, and home-school interaction". General-purpose tool-based mobile applications that are not developed for the education system and whose main users are not for faculty and students, and that are not for the application of the education system are not included in the filing scope.

　　(B) the types of educational mobile applications

　　In order to implement the "double reduction" work requirements, educational mobile applications are divided into two types: discipline training (primary and secondary schools) and non-discipline training (non-primary and secondary schools).

　　1. Discipline training. According to the notice of the General Office of the Ministry of Education on Further Defining the Scope of Off-campus Training in Compulsory Education (Letter No.3 from the Office of Education Supervision [2021]), the mobile application of education contains disciplines such as morality and rule of law, Chinese, history, geography, mathematics, foreign languages (English, Japanese, Russian), physics, chemistry and biology. The education mobile application that provides the above-mentioned discipline training services for compulsory education and senior high school students through the education mobile application is collectively referred to as "discipline training education mobile application for primary and secondary schools" (referred to as "discipline training").

　　2. Non-disciplinary training. Mobile education applications do not contain the training contents of the above disciplines, but mainly provide sports (or sports and health), art (or music and fine arts), comprehensive practical activities (including information technology education, labor and technical education), education and teaching management, home-school communication and other contents for primary and secondary school students, and provide educational services for non-primary and secondary school students. They are collectively referred to as "mobile education applications for non-primary and secondary school discipline training" (referred to as "non-discipline training").

　　(three) providers and users for the record

　　Providers who belong to the above educational mobile applications shall, in accordance with the principle of "everything should be prepared", timely record the providers on the National Education Mobile Internet Application Record Management Platform (https://app.eduyun.cn/) and implement relevant requirements; As users of educational mobile applications, municipal and district education administrative departments and their subordinate units and schools at all levels should establish a selection system for educational mobile applications, select educational mobile applications that have been filed by providers, and record users in time. Education administrative departments and schools are not allowed to choose unregistered educational mobile applications, and students and parents are not allowed to charge any fees for unified selection.

　　Third, the filing conditions

　　Providers of educational mobile applications and their products should strictly abide by national laws and regulations, adhere to the party’s educational policy, implement the fundamental requirements of Lide Shuren, conform to the policy of "double reduction" and reflect the orientation of quality education. The content provided must not contain negative information, bad information, game links and advertisements. Establish a data guarantee mechanism covering the collection, storage, transmission and use of personal information. The collection and use of minor information shall obtain the consent and authorization of the guardian, and personal information shall not be disclosed, sold or provided to others, so as to earnestly fulfill the legal responsibility of protecting personal information and ensure the information safety of students and parents.

　　(1) According to the requirements of the central "double reduction" document, those who engage in online discipline training in primary and secondary schools need to obtain online discipline training licenses for primary and secondary schools. The provider of mobile application for discipline training education must be a non-profit legal person who has obtained the school license of the provincial education administrative department, registered by the civil affairs department and established according to law, and engaged in discipline training in the online compulsory education stage.

　　(2) The educational mobile application shall not provide a platform (or function) for unauthorized institutions (or individuals) to carry out discipline training.

　　(3) The educational mobile application shall not provide and spread the functions such as "taking photos and searching questions" which can slow down the thinking ability of primary and secondary school students, affect students’ independent thinking and violate the laws of education and teaching.

　　(4) The education mobile application provider submits the filing application through the national education mobile Internet application filing management platform as required, and the Municipal Education Commission shall review it in accordance with the Measures for the Administration of Education Mobile Internet Application Filing of the Ministry of Education and report it to the Ministry of Education for review and filing.

　　(five) no longer accept pre-school online training and education mobile application for the record, has been filed to be revoked.

　　(six) education mobile application providers should establish and improve the information content audit management mechanism, establish and improve account management, emergency disposal and other management measures, equipped with professionals to adapt to the scale of services, to provide business services and technical support; Formulate and publicize management rules and platform conventions, and sign service agreements with registered users; Consciously accept social supervision, set up eye-catching and convenient consultation and complaint entrances, improve the mechanisms of acceptance, disposal and feedback, and handle user demands in a timely manner.

　　Fourth, strengthen collaborative supervision

　　(1) The Municipal Education Commission takes the lead in reviewing the filing of educational mobile applications, is responsible for overall coordination, guiding and supervising the school to implement the main responsibility, is responsible for reviewing the content of educational mobile applications for filing, and accepts relevant social complaints and reports (see the "Notice for Complaints" on the filing management platform of educational mobile Internet applications for specific complaints and reports). For those who violate laws, regulations and policies, they will jointly carry out joint governance with relevant departments.

　　(2) The Municipal Communications Administration is responsible for the filing and review of the Internet information service (ICP) for educational mobile applications, taking the license of the online off-campus training institution of the education department as the precondition for the ICP filing of the mobile application providers of discipline training education, and cooperating with the education administrative department to jointly supervise the mobile application of discipline training education in advance; For illegal education mobile applications confirmed by relevant departments, they shall be ordered to make corrections within a time limit; Those who refuse to make corrections shall be ordered to close down and do a good job of supervision afterwards.

　　(3) The Information Office of the Municipal Party Committee is responsible for urging service providers of distribution platforms such as local application stores to strengthen the verification of educational mobile applications, keep abreast of the updates of educational mobile applications, and take corresponding measures in time if violations are found.

　　V. Publish the black-and-white list

　　The Municipal Education Commission established a publicity column on the official website, dynamically published the black-and-white list of educational mobile applications, promptly publicized the educational mobile applications and their providers that have been audited and filed, rectified within a time limit for violations of laws and regulations, blacklisted those that failed to rectify or refused to rectify within the time limit, and jointly investigated and dealt with by the Municipal Party Committee Information Office and the Municipal Administration Bureau.

Beijing Municipal Commission of Education　　　　

Office of Network Security and Informatization Committee of Beijing Municipal Committee of the Communist Party of China　　　　

Beijing Communications Administration Bureau　　　　

April 27, 2022　　

　　[car home new car on the market] On January 1, 2023, the new model (|) was officially launched, and four models continued to be launched.The price range is 300,000-386,000 yuan.. According to different configurations, the Krypton 001 has two kinds of power and three kinds of cruising range, of which the maximum power of the double motor is 400kW and the acceleration time of 0-100km/h is only 3.8s s. For users who have higher requirements for cruising range, the new ZEEKR 001 WE 100kWh version is limited to 1000 sets of cruising suits.The retail price is 103,000 yuan,Using CTP 3.0 Kirin battery, the rear motor contains silicon carbide technology, and the CLTC cruising range of 140kWh battery pack can reach 1032km under comprehensive working conditions.

　　According to official sources, the delivery volume of Krypton 001 in December 2022 continued to break through 10,000, reaching11337Taiwan, a year-on-year increase.198.7%。In 2022, the cumulative delivery of krypton 001 reached71941Taiwan, overfulfilled the target. Extreme Krypton 001 is the first pure electric luxury car of China brand to deliver more than 10,000 bicycles per month, and it is constantly refreshing the delivery record, with an average large order amount exceeding 336,000 yuan.

　　In terms of appearance, the new Extreme Krypton 001 has added three car colors: Yuguang Orange, Extreme Blue and Extreme Night Black, with a total of six car colors to choose from. Among them, the YOU version introduces the original sports suit-Z-SPORT advanced sports suit, which includes Yuguang orange body color (including contrasting roof), orange gray Alcantara interior and adaptive racing seat. The 22-inch multi-spoke sports forged wheel rim +Brembo six-piston caliper+high-performance, large-size perforated brake disc+brand high-performance tires can better meet the young users who like sports cars.

　　In the interior part, the new car comes standard with NAPPA top leather interior, providing four choices of carbon black/nitrogen blue/platinum gray/titanium brown, with Alcantara interior splicing coating, Microfiber microfiber ceiling and contrast quilting, which highlights the luxurious atmosphere inside the car. The seats are all upgraded to Monaco NAPPA full-grain leather, with front seat heating/ventilation/massage/memory functions, and the whole car is equipped with electric adjustable seats.

　　The configuration part is the upgrade focus of the new Krypton 001. The new car comes standard with silent electric suction doors, and the YOU version is also equipped with inductive automatic doors. In addition, the new car comes standard with an intelligent constant temperature air conditioning package, including a three-zone automatic constant temperature air conditioner, a 5.7-inch rear passenger multi-function touch screen and an intelligent fragrance system.

　　Through OTA, ZEEKR OS 4.0 provides an extremely proactive interactive system, which can directly reach high-frequency applications. Users can realize a light-level intelligent interactive experience with only one click. Through the optimization of thermal management system-drive system, the CLTC comprehensive working condition endurance of Krypton 001 is improved by 6-10km. It is worth mentioning that, according to the official disclosure, the NZP high-speed autonomous navigation auxiliary system will start a comprehensive pioneer test in January 2023. High-speed NZP fully considers the complex traffic jams faced by domestic users, and solves many pain points of similar functions. It will be first implemented on high-speed and elevated roads in Shanghai and Hangzhou.

　　In terms of power, Krypton 001 has two kinds of power: double motors and single motors. The maximum power of the double motors is 400kW, and the acceleration time of 0-100km/h is only 3.8s s.. The cruising range of the single-motor version equipped with a ternary lithium battery with a capacity of 100kWh is upgraded to 741km under CLTC conditions, and the cruising range of the dual-motor version is upgraded to 656km；; The cruising range of the dual-motor version with 86kWh battery pack was upgraded to 546km. For users who have higher requirements for cruising range, the new version of Krypton 001 WE 100kWh is limited to 1000 sets of cruising range suits, using CTP 3.0 Kirin battery, and the rear motor contains silicon carbide technology. The CLTC comprehensive working range of 140kWh battery pack can reach 1032km. (Compile/car home zhang xiaodan)

　　[Chexun. com]On December 27th, Changan Automobile’s brand-new MPV Auchan was officially launched, and four new models were launched, with a price of 51,900-64,900 yuan. The new car will be positioned in the home market in the future, and all the cars are equipped with 1.5L engines.

　　Auchan’s overall configuration is relatively high. The whole system is equipped with front and rear indoor lighting, cigarette lighters, the first and third rows of 12V power supplies and the same color inner door opening handles, the front and rear electric windows, the driver’s seat door and window glass drop at one touch, the automatic anti-glare inside and outside rearview mirrors, the sun visor with makeup mirror for the front and rear drivers, the front manual independent air conditioner and the air outlet of the second row of air conditioners with wind direction and air volume adjustment. Driving computer display screen, front and rear driver’s seat airbags, safety system prompt, ISO FIX child seat interface, engine electronic anti-theft, in-vehicle central locking, remote control key, all-vehicle three-point seat belt, door ajar warning light, independent display of five-door opening and closing status, rear door child lock, automatic locking and parking unlocking, ABS+EBD safety configuration, AUX/USB/Ipod external audio interface.

　　Auchan’s length, width and height are 4465/1725/1700 mm respectively (the height of standard and fashion models is 1685 mm) and the wheelbase is 2680 mm. With the 2+3+2 seat design, it is possible to launch a 6-seat model in the future, and the trunk space is spacious, and the rear two rows of seats can be leveled. The interior design is fashionable and atmospheric, and the design of connecting the LCD screen instrument panel and the central control screen refers to the Mercedes-Benz S-Class sedan.

　　In addition to the standard model, the other models are equipped with electrically adjustable rearview mirrors, rear wipers and rear window defrosting and defogging functions. And the 7-inch center console color touch screen, which has mobile phone mapping, car phone and Bluetooth functions, as well as multimedia playback such as DVD and other support functions. The inner door handle of the top model is chrome-plated, with rearview mirror heating function and GPS navigation. The technology configuration also includes HBA+TCS+ESP body stability system, HHC uphill assist and front and rear reversing radar, and radar distance display function.

　　In terms of power, Auchan is equipped with a 1.5L engine, with an output power of 84KW, a maximum torque of 148N.m, and a fuel consumption of 6.8L under 100 kilometers. The transmission system is matched with a 5-speed manual transmission, which is the same model as Changan Yidong and Yuexiang V7. In the future, Auchan will also add an automatic turbocharged model equipped with a 1.0T engine and Aisin 6AT gearbox. Auchan’s suspension system adopts the combination of front McPherson independent suspension, rear torsion beam semi-independent suspension and front drive. It comes standard with EPS electric power steering system, which makes it closer to cars, and is different from the commercial MPV that everyone has been exposed to in the traditional sense. As a whole, it is developed at the level of cars. Among them, the exterior design is the responsibility of Changan European Design Center, and the interior design is developed by Changan Japanese design team. The NVH idle speed test is only 39 decibels.

Changan Auchan competing model Baojun 730 and popular S500

Changan Auchan competing models Yingzhi 737 and Wuling Hongguang S1

　　Auchan’s positioning is different from the previous positioning of Changan commercial vehicle brand. At present, MPV in China can be roughly divided into commercial MPV represented by Buick GL8 and commercial MPV represented by Wuling Hongguang. Changan Auchan is positioned as another emerging market, that is, home MPV. Domestic MPVs are often not expensive, but the overall quality requirements and comfort are stronger than commercial MPVs. In the past, Changan Ounuo’s competitors were Scenery 360 and Wuling Hongguang. However, Auchan’s potential consumer groups do pay attention to household consumers, which is close to Baojun 730, but latecomers such as popular S500, Yingzhi 737 and Wuling Hongguang S1 will also make efforts in this market segment. It is believed that Auchan has a high overall quality and cost performance after listing, and can perform well in the home MPV market.

Zhu Huarong, President of Changan Automobile

　　At the press conference, we also learned from Mr. Zhu Huarong, President of Changan Automobile, and the official of Changan Automobile. In 2016, Changan Automobile will launch 14 new products and 167 new models by 2025. The 14 new models to be launched next year include 9 new energy products. In addition, Changan Automobile will spend 5% of its annual sales on research and development. Changan Auchan’s spare parts and R&D links are completely built according to passenger cars. In the future, Changan’s commercial products will extend from MPV to SUV market, as well as seven multifunctional products between MPV and SUV. In the first half of 2016, Changan Commercial Co., Ltd. will also release a changan CX70 positioned in the SUV market, including the steering wheel and other parts, which will be shared with Auchan and CS75. Thirteen new products will be launched before 2025.

On January 1, 2024,Dongfeng Nissan’s new car, the 2024 Nissan Sylphy Classic, was officially launched. The new car offers three models (1.6 XE CVT Comfort Edition, 1.6 XL CVT Deluxe Edition and 1.6L XV CVT Exclusive Edition), and the price is 108,600 yuan and 122,600 yuan. As a modified model of the year, the appearance/interior of the new car has not changed significantly, mainly adding exclusive models (configuration and price have increased).

In terms of power system, the new car continues to use a 1.6L naturally aspirated engine, matching the CVT gearbox, with a maximum power of 90KW.

Pictured: 2022 (redesigned) Nissan Sylphy Classic 1.6 XE CVT Comfort Edition

The 2024 Nissan Sylphy Classic offers three models, namely, the comfort version, the luxury version and the exclusive version, and the prices are 108,600 yuan, 118,600 yuan and 122,600 yuan respectively.

Compared with the 2022 (redesigned) model, the 2024 Sylphy Classic adds a exclusive model, while the original price and configuration of the comfort and luxury versions remain unchanged.

On the whole, the configuration of the newly added exclusive models has been increased: intelligent remote control key, keyless entry/start, LED low beam/daytime running lights, and automatic headlights.

In the design part, the front face of the new car continues to use the V-shaped air intake grille+chrome-plated parts, while the headlights similar to the three-level shape remain unchanged. In addition, the left and right sides of the front enclosure and the central position have also added blackened decorative pieces to enhance the vitality and dynamic atmosphere of the front face.

The body size of the new car is: 4631*1760*1503mm, with a wheelbase of 2700mm, which is a compact car.

In addition, the new car also provides 16-inch wheels, compared with 195/60 R16 in tyre size.

In the rear part, the left and right independent taillights are used in the rear of the new car, and a bright chrome-plated decorative piece is added to the tail box cover. In addition, a large area of blackened decoration is also added to the bottom of the rear enclosure, while the exhaust adopts a hidden layout.

In the interior design part, the center console area of the new car is equipped with a three-position steering wheel, a mechanical instrument panel and an 8-inch embedded central control panel (luxury version/exclusive version).

At the same time, the new car also continues to use the mechanical shift mechanism, and also retains the physical button+knob air conditioning control mode.

The 1.6 XE CVT Comfort Edition is not equipped with a central control panel.

The 8-inch central control panel car machine supports GPS online navigation, 4G network, OTA upgrade, voice recognition control and other functions.

In the seat part, the car adopts a five-seat layout, and the seat is wrapped with fabric or imitation leather.

In terms of the functionality of the seats, all the seats in the car support manual adjustment, while the Deluxe Edition/Privileged Edition also provides the central armrest/cup holder of the rear seat.

As for the power unit, the new car continues to use a 1.6L naturally aspirated engine, which matches the CVT gearbox. The maximum power is 90KW(122Ps), the maximum torque is 155N·m, the acceleration at zero speed is 12.1 seconds, the maximum speed is 180km/h, and the comprehensive fuel consumption under WLTC conditions is 5.94L L.

1905 movie network feature The high-scoring suspense action movie starring the director, screenwriter,,,,, was released nationwide on March 1.

The film was widely praised during its premiere. Douban’s score rose all the way to 8.4 points, making it the highest-scoring film released in the mainland in 2024. Some media even said that "The Three Evils in the Week" is expected to become the first box office black horse after the Spring Festival in 2024. So what’s the point of this movie?

With allusions, profound connotations

The title of the movie "Removal of the Three Harmies in Zhou Chu" is cleverly adapted from the allusions of the same name found in "Shishuo Xinyu" and "Jin Shu · Zhouchu Biography". According to the literature, the young man Zhou Chu was burly and powerful, but he ran rampant in the countryside and was hated by his neighbors. After Zhou Chu killed the tiger and the dragon alone, he himself turned his prodigal son back and corrected his evil, so far all three evils have been eliminated.

The gangster Chen Guilin (Ruan Jingtian, played) in the movie is determined to imitate Zhou Shu, one person to eliminate the three gangsters, and remove the top two on the wanted list one by one, until the curtain call of his life of self-redemption is completed. It can be described as the contemporary "Zhou Chu eliminates the three evils".

The historical allusion is a legend of killing people, while the film focuses on the stranger life of a killer, who attempts to use killing to find the value of life. Chen Guilin’s motivation is to "leave his name behind", but during the journey he gradually found his true self and realized spiritual freedom.

The film explores the reaction of "greed, hatred and delusion" from the perspective of absurd self-salvation, which not only brings a sense of genre film, but also has a strong social warning significance.

Heavy metaphor, detailed and in-depth

Among the hot words mentioned in the public opinion comments on the whole network of "Zhouzhou Removal of the Three Harmful", there was also a hot movie last year. Compared with the straightforward "malicious" of "All-in-One", "Zhouzhou Removal of the Three Harmful" has more metaphors in the film.

The English title of the film is "The Pig, The Snake and The Pigeon", which literally translates to pigs, snakes and pigeons. These three animals are also symbols of the three poisons of ignorance, hatred and greed mentioned in Buddhist texts. In the film, pigs, snakes and pigeons are also used to represent the three most wanted criminals.

The so-called "pig" refers to the movie’s protagonist, Chen Guilin, who always wears a watch in the image of a pig, representing ignorance and a dark and unintelligent heart. At the beginning of the movie, he is arrogant after the murder, and it is not until he is told that he is terminally ill and has less than half a year to live that he begins to reflect on "what kind of life to choose." Chen Guilin’s evil is his obsession, his obsession with finding and proving the meaning of his existence.

The image represented by the snake is the character of the second evil "Aberdeen" Xu Weiqiang in the movie. He has a tattoo about the snake on his body, which symbolizes hatred, intolerance and fierce violence. In the first appearance of the film, through the contrast of a smile and a rage, a short scene created a very full image of Xu Weiqiang.

The pigeon represented Lin Luhe, the third evil in the movie, and there was a pigeon tattoo on his back, which referred to unbridled greed. In the movie, he didn’t just do evil alone, but organized a criminal gang, established an organization "New Mind House" to play tricks, cheat everywhere, and play with the common people.

What kind of grievances and entanglements exist between these three wanted criminals, how will Chen Guilin’s pursuit story unfold, and how will the strong confrontation end?

Mixed styles, unique types

In terms of film style, "Removing the Three Evils in a Week" combines three styles: film noir, Hong Kong-style gangster film, and desktop grotesque film. The director’s mastery blends together a variety of styles and types, forming a distinct feature of this film.

Themes, "Zhou Zhuan get rid of the three evils" from the Hong Kong crime theme developed, from the root of it with a certain Chinese traditional martial arts color, Chen Guilin in the film is like a walking rivers and lakes knight, get rid of violence and good, for the people;

But at the same time, the movie also pays tribute to the classic Westerns. People like Chen Guilin are also criminals who have committed heinous crimes and will eventually face the fate of punishment. Just like the cowboys in Westerns, although they use violence to suppress violence and eliminate criminals by violent means, civilized towns cannot tolerate violence, so they are doomed to be exiled to the more barbaric and distant west.

Under the aesthetics of violence, "Removing the Three Evils in a Week" tells a story about the values of the outlook on life. Killing is not for profit or revenge, but out of the obsession of outlaws with their own value, with a strong fatalism.

"Removing the Three Evils in a Week" takes a character in the mud as the protagonist of the film, respects his motives, and gives him the opportunity to be "reborn". I believe that after watching this movie, the audience will not feel gloomy, but can get full and high-spirited strength.

　　At 10:49 on May 17, 2023, our country successfully launched the 56th Beidou navigation satellite with the Long March 3B carrier rocket at the Xichang Satellite Launch Center. The satellite is a geostationary orbit satellite and is the first backup satellite of our country’s Beidou-3 project. After entering the orbit and completing the in-orbit test, it will be connected to the Beidou satellite navigation system. This launch is the first mission after three years of high-density networking of the Beidou-3 project.

　　The launch of the satellite will further enhance the system service performance, which is of great significance for promoting the characteristic services of the Beidou system and supporting the large-scale application of the Beidou system. The satellite realizes on-orbit hot backup of existing geostationary orbit satellites, which will enhance the availability and robustness of the system, increase the existing regional short message communication capacity of the system by one-third, improve the satellite-based enhancement and precision single-point positioning service performance, and help users achieve fast and high-precision positioning.

　　The Beidou navigation satellite and supporting launch vehicle launched this time were jointly developed by the China Academy of Space Technology and the China Academy of Launch Vehicle Technology, which are affiliated to the China Aerospace Science and Technology Corporation. This is the 473rd flight of the Long March series of launch vehicles.

　　(CCTV reporters, Wang Gang, Liu Jie)

The cornerstone of the First Automobile Factory engraved with Mao Zedong’s inscription

In May 1958, China’s first "Dongfeng" brand car was successfully trial-produced

In the early days of the founding of New China, Mao Zedong said: What can we make now? We can make tables and chairs, tea bowls and pots, grow grain, grind flour, and make paper, but we can’t make a car, an airplane, a tank, or a tractor.

Achieving socialist industrialization is a natural requirement and a necessary condition for a country to become independent and prosperous, and is the foundation and premise for building a modern socialist power. During the "First Five-Year Plan" period, the state concentrated its resources to establish an independent and relatively complete industrial system and national economic system in a short period of time, achieving rapid growth of the national economy, which was of far-reaching significance to China’s later industrial development.

The cornerstone of the "First Automobile Factory Groundbreaking Memorial" displayed in the History Exhibition Hall of the Communist Party of China, inscribed by Mao Zedong, is 120.5 centimeters long, 70 centimeters high, 5.5 centimeters thick, and weighs 250 kilograms. The texture of white marble is an important witness to the history of industrial construction in New China.

On June 15, 1953, Mao Zedong delivered a speech at the Politburo meeting of the Central Committee, formally proposing the general line for the transition period. Faced with the lack of funds, technology and talents, to establish China’s own industrial system, it is necessary to formulate detailed plans and concentrate the limited human, material and financial resources to build a number of urgently needed major projects.

Under the personal guidance of Mao Zedong and the direct help of the Soviet Union, the first five-year plan was formulated by Zhou Enlai, Chen Yun, Li Fuchun, etc., and the strategic decision to give priority to the development of heavy industry was made. Adhering to the policy of "self-reliance first, and foreign aid as a supplement", the preliminary industrial layout was completed. During the "First Five-Year Plan" period, a total of 694 large and medium-sized construction projects were arranged, and 921 were actually constructed, including 156 construction projects aided by the Soviet Union, focusing on the development of heavy industry, energy, raw materials, machine manufacturing and other basic industrial projects.

In 1953, the People’s Daily published a New Year’s Day editorial announcing that China had begun to implement the first five-year plan, calling on the people of the whole country to work together with one heart and one mind and actively strive for the realization of industrialization. Building a prosperous and strong modern industrial country is the dream of several generations of Chinese sons and daughters. Faced with the "poor and white" family background and the heavy blockade in the world, the Chinese people have a common dream, a foothold in the sky, and energy. Facing difficulties, the Chinese people have carried out large-scale industrial construction in full swing across the country.

As early as Mao Zedong’s first visit to the Soviet Union, he visited the Stalin Automobile Factory. At that time, he pointed to the cars that drove down the assembly line and said to his entourage: "We also want to have such a large factory!" On July 15, 1953, the first automobile industrial base of New China, Changchun First Automobile Factory, held a groundbreaking ceremony in a barren suburb of Changchun. Mao Zedong personally wrote the cornerstone inscription. Instead of adopting the proposed "Mao Zedong Automobile Factory" or "New China Automobile Factory", he named it the First Automobile Factory because he said: "We will soon have a second and a third."

600 million yuan was invested in the construction of the FAW, which is equivalent to one yuan for 600 million people in the country. On July 13, 1956, we forcefully announced that the first car in New China was successfully trial-produced. "From today onwards, the history of China’s inability to manufacture cars is over, and our own cars will be driven out of here more and more day by day." Mao Zedong personally picked up the pen and wrote the word "Liberation". The first batch of 12 "Liberation" brand cars drove off the assembly line and became an eternal and precious freeze frame in the history of the Republic. The rejoicing masses, as the song made up at that time sang: "Looking forward to the stars and the moon, the domestic car that I hoped for really left the factory." Just one year later, Changchun FAW completed the production of 4,000 vehicles stipulated in the first five-year plan six months and five days ahead of schedule.

In 1958, the Changchun FAW Factory produced China’s first domestically produced car, the Dongfeng brand car. After the manufacture was completed, it was instructed by the central government to be shipped by train to Beijing. When it drove off the platform, it was almost unable to leave the Beijing Railway Station due to the enthusiastic crowd competing to watch. Dongfeng originated from Mao Zedong’s famous statement on the international situation – "Dongfeng overwhelms the westerly wind". The word "Dongfeng" on the front of the car was originally Chinese pinyin. On the eve of the Dongfeng car arriving in Beijing and driving into Zhongnanhai, according to the suggestion of the then director of the General Office of the Central Committee ***, in order to highlight the cars produced by the Chinese themselves and replace them with Chinese characters, FAW staff went to the People’s Daily overnight to photocopy Mao Zedong’s original handwriting of "Dongfeng overwhelms the westerly wind". It was replaced in an auto repair shop in Dengshikou, and a golden dragon was about to be vacated in the front of the car, which was very Chinese. Mao Zedong took it in person and said happily: "We took a car made by ourselves!"

While the automobile industry was booming, various industrial categories were also in full swing. On December 26, 1953, the three major projects of Angang, consisting of a large rolling mill, a seamless steel pipe plant, and a No. 7 blast furnace, were completed and put into operation. At the same time, new steel production bases were deployed, and a new layout of the steel industry in New China was initially formed. The petroleum industry, chemical industry, and weapons industry have all achieved a certain degree of development, focusing on the construction of emerging industrial sectors such as aviation and electronics, and the creation of new cutting-edge industries in the nuclear and aerospace industries. In 1956, Shenyang Aircraft Factory produced the first new jet fighter; in 1958, the first Dongfanghong tractor was born in the first tractor factory located in Luoyang City… In that fiery construction era, China, which used to import iron nails and matches, achieved one zero breakthrough after another, and gradually established an industrial economic system under the leadership of the socialist state-run economy, which made our country’s industrial economy recover and develop rapidly under extremely difficult conditions.

Today, steel dragons meander vertically and horizontally, phoenixes spread their wings at Daxing Airport, Chang’e Tiangong catches the moon in nine days, and flood dragons and snow dragons catch turtles in five oceans. Over the past 70 years, China’s industry has achieved one "zero breakthrough" after another, and Chinese manufacturing and Chinese creation are gradually leading the world.

(History Exhibition Hall of the Communist Party of China, contributed)

In recent years, with the continuous development of automobile technology, many new models have been introduced by major manufacturers, some of which have attracted much attention at the end of the year. This paper will comprehensively analyze three high-profile models from different angles, namely Nissan Sylphy, Tesla Model Y and Volkswagen LaVida.

appearance design

First of all, let’s take a look at the design of these three models.

Nissan Sylphy is highly praised for its dynamic appearance. The body lines are smooth, dynamic and steady, giving people a visual impact with a sense of fashion and luxury. Tesla Model Y adopts a fashionable design concept, and its unique lines and bold appearance make it a beautiful landscape on the road.

Volkswagen LaVida attracts attention with its exquisite appearance, and every detail has been carefully carved, making the overall appearance more luxurious and atmospheric.

Luxury of interior

In addition to the appearance, the interior design of the vehicle is also an important factor to consider when buying a car. Nissan Sylphy also performed well in the interior, and the sense of luxury was beyond words.

Selected materials and exquisite craftsmanship make the interior space a private luxury space for drivers and passengers. The interior design of Tesla Model Y highlights the sense of fashion and technology. The large central control screen and high-quality interior materials give people a sense of the future. Volkswagen LaVida, on the other hand, takes its luxury interior as its selling point, and its wood grain decoration and high-grade seats make driving a luxury enjoyment.

Configuration richness

In terms of configuration, these three models also strive to stand out in the same class. Nissan Sylphy is rich in configuration, including advanced safety system, intelligent driving assistance and other functions, providing drivers with a more comprehensive car experience.

Tesla Model Y has attracted much attention for its leading electric vehicle technology. Its advanced automatic driving system and strong endurance make it one step ahead in technology configuration. Volkswagen LaVida, on the other hand, pays attention to safety performance and is equipped with advanced driver assistance system, which makes driving more secure.

Cost performance analysis

When buying a car, consumers often pay more attention to cost performance.

Nissan Sylphy shows excellent cost performance with its dynamic appearance, luxurious interior and rich configuration. Although the price of Tesla Model Y is high, its advanced electric vehicle technology and endurance offset the high price to some extent. Volkswagen LaVida provides a good choice for consumers with its plain price and rich configuration.

Comparison of endurance

In the current trend of electric vehicles, endurance has become a crucial indicator. Tesla Model Y stands out with its strong endurance, providing consumers with longer driving mileage, making electric vehicles a more practical means of transportation.

In contrast, Nissan Sylphy and Volkswagen LaVida are slightly inferior in this respect. Although they are sufficient in daily use, there is still room for improvement compared with the future development trend of electric vehicles.

Safety performance comparison

In the automotive field, safety performance has always been the focus of consumers’ attention.

These three models have excellent performance in safety performance. Nissan Sylphy has passed the advanced safety system and a number of safety tests to ensure the safety of drivers and passengers. Tesla Model Y provides drivers with more comprehensive protection with its intelligent driver assistance system and advanced collision safety technology.

Volkswagen LaVida also pays attention to safety performance and is equipped with a number of driver assistance systems to make driving more secure and reliable.

Based on the above analysis, Nissan Sylphy, Tesla Model Y and Volkswagen LaVida each have unique advantages in design, interior luxury, configuration richness, cost performance, endurance and safety performance.

When buying a car, consumers can weigh the advantages and disadvantages of these aspects according to their personal needs and preferences, and choose the model that best meets their own needs. With the continuous progress of science and technology, the automobile industry will also usher in more innovations and changes, and the future models will be more intelligent, environmentally friendly and safe, providing consumers with a richer driving experience.